Model list JPKPD

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Exposure–response analyses of blood pressure and heart rate changes for methylphenidate in healthy adultsLiang LiYaning WangRamana S. UppoorMehul U. MehtaTiffany FarchioneMitchell V. MathisHao Zhuno?nohttps://link.springer.com/article/10.1007/s10928-017-9513-5
Exposure–disease response analysis of natalizumab in subjects with multiple sclerosisKumar Kandadi MuralidharanDeb SteinerDiogo AmarantePei-Ran HoDan MikolJacob ElkinsMeena SubramanyamIvan Nestorovno?nohttps://link.springer.com/article/10.1007/s10928-017-9514-4
Population pharmacokinetics and pharmacodynamics of IONIS-GCGRRx, an antisense oligonucleotide for type 2 diabetes mellitus: a red blood cell lifespan modelKenneth T. Luu Erin S. MorganSanjay BhanotRichard GearyAnne SmithClaudette BethuneLynnetta WattsScott HenryYanfeng Wangno, GOF onlyNM?nohttps://link.springer.com/article/10.1007/s10928-017-9505-5
Modeling of free fatty acid dynamics: insulin and nicotinic acid resistance under acute and chronic treatmentsRobert Andersson Tobias KroonJoachim AlmquistMats JirstrandNicholas D. OakesNeil D. EvansMichael J. ChappelJohan Gabrielssonnomathematicanohttps://link.springer.com/article/10.1007/s10928-017-9512-6
A two-step deconvolution-analysis-informed population pharmacodynamic modeling approach for drugs targeting pulsatile endogenous compoundsMichiel J. van Esdonk Jacobus Burggraaf Piet H. van der Graaf Jasper StevensyesNMnohttps://link.springer.com/article/10.1007/s10928-017-9526-0
Model-based meta-analysis for comparing Vitamin D2 and D3 parent-metabolite pharmacokineticsAlanna S. Ocampo-Pelland Marc R. GastonguayMatthew M. RiggsyesNMnohttps://link.springer.com/article/10.1007/s10928-017-9525-1
Impact of altered endogenous IgG on unspecific mAb clearanceSaskia Fuhrmann Charlotte Kloft Wilhelm Huisingano?nohttps://link.springer.com/article/10.1007/s10928-017-9524-2
Estimation of QT interval prolongation through model-averagingPeter L. Bonateno?nohttps://link.springer.com/article/10.1007/s10928-017-9523-3
Analysis of opioid consumption in clinical trials: a simulation based analysis of power of four approachesRasmus Vestergaard JuulJoakim NybergMads KreilgaardLona Louring ChristrupUlrika S. H. SimonssonTrine Meldgaard LundnoNMNAhttps://link.springer.com/article/10.1007/s10928-017-9522-4
PK–PD Compass: bringing infectious diseases pharmacometrics to the patient’s bedsideCatharine C. Bulik Justin C. BaderLi ZhangScott A. Van WartChristopher M. RubinoSujata M. BhavnaniKim L. SweeneyPaul G. Ambroseno?NAhttps://link.springer.com/article/10.1007/s10928-017-9518-0
A whole-body physiologically based pharmacokinetic (WB-PBPK) model of ciprofloxacin: a step towards predicting bacterial killing at sites of infectionMuhammad W. Sadiq Elisabet I. Nielsen Dalia Khachman Jean-Marie Conil Bernard GeorgesGeorges HouinCeline M. LaffontMats O. KarlssonLena E. FribergyesNMnoCelinehttps://link.springer.com/article/10.1007/s10928-016-9486-9
Drug disposition model of radiolabeled etelcalcetide in patients with chronic kidney disease and secondary hyperparathyroidism on hemodialysisLiviawati WuMurad MelhemEmail authorRaju SubramanianBenjamin WunoNMnohttps://link.springer.com/article/10.1007/s10928-016-9503-z
Quantitative characterization of in vitro bystander effect of antibody-drug conjugatesAman P. SinghSharad SharmaDhaval K. Shahno?nohttps://link.springer.com/article/10.1007%2Fs10928-016-9495-8
A cell-level model of pharmacodynamics-mediated drug dispositionWojciech KrzyzanskiJohn M. Harrold Liviawati S. WuJuan Jose Perez-Ruixono?nohttps://link.springer.com/article/10.1007/s10928-016-9491-z
Analysis of peginterferon β-1a exposure and Gd-enhanced lesion or T2 lesion response in relapsing-remitting multiple sclerosis patientsnoNMnoCelinehttps://link.springer.com/article/10.1007%2Fs10928-016-9477-x
Population pharmacokinetic/pharmacodynamic modeling of histamine response measured by histamine iontophoresis laser DopplerXiaoxi LiuBridgette L. JonesJessica K. RobertsCatherine M. Sherwinno?nohttps://link.springer.com/article/10.1007/s10928-016-9478-9
Model-based pharmacokinetic analysis of elotuzumab in patients with relapsed/refractory multiple myelomaLeonid GibianskyChaitali PasseyAmit RoyAkintunde BelloManish GuptayesNMnohttps://link.springer.com/article/10.1007/s10928-016-9469-x
Models for the red blood cell lifespanno?nohttps://link.springer.com/article/10.1007/s10928-016-9470-4
Minimal physiologically-based pharmacokinetic (mPBPK) model for a monoclonal antibody against interleukin-6 in mice with collagen-induced arthritisXi ChenXiling JiangWilliam J. JuskoHonghui Zhou Weirong Wangno?nohttps://link.springer.com/article/10.1007/s10928-016-9472-2
The pharmacokinetics of dexmedetomidine during long-term infusion in critically ill pediatric patients. A Bayesian approach with informative priorsPaweł Wiczling Alicja Bartkowska-ŚniatkowskaEmail authorOliwia SzerkusDanuta SilukJowita Rosada-KurasińskaJustyna WarzybokAgnieszka BorsukRoman KaliszanEdmund GrześkowiakAgnieszka BienertyesWinbugs, Matlabnohttps://link.springer.com/article/10.1007/s10928-016-9474-0
Predicting the probability of successful efficacy of a dissociated agonist of the glucocorticoid receptor from dose–response analysisDaniela J. ConradoSriram KrishnaswamiSatoshi ShojiSheela KolluriJudith Hey-HadaviDorothy McCabeRicardo RojoBrinda K. TammaraNMnohttps://link.springer.com/article/10.1007/s10928-016-9475-z
Concentration-QT analysis of the randomized, placebo- and moxifloxacin-controlled thorough QT study of umeclidinium monotherapy and umeclidinium/vilanterol combination in healthy subjectsRashmi Mehta, Michelle Green, Bela Patel, Jonathan Wagg…no?nohttps://link.springer.com/article/10.1007%2Fs10928-015-9461-x
Determination of a suitable voriconazole pharmacokinetic model for personalised dosingDavid A. J. McDougall Jennifer MartinE. Geoffrey PlayfordBruce Greenno?nohttps://link.springer.com/article/10.1007/s10928-015-9462-9
Organ data from the developing Göttingen minipig: first steps towards a juvenile PBPK modelEls Van PeerNoel DownesChristophe CasteleynChris Van GinnekenArie WeerenSteven Van Cruchtenno?nohttps://link.springer.com/journal/10928/43/2/page/1
Model-based meta-analysis for development of a population-pharmacokinetic (PPK) model for Vitamin D3 and its 25OHD3 metabolite using both individual and arm-level dataAlanna S. Ocampo-Pelland Marc R. GastonguayJonathan F. FrenchMatthew M. Riggsno?nohttps://link.springer.com/article/10.1007/s10928-016-9465-1
Identifiability of PBPK models with applications to dimethylarsinic acid exposureRamon I. GarciaJoseph G. IbrahimJohn F. WambaughElaina M. KenyonR. Woodrow SetzerEmail authorno?nohttps://link.springer.com/article/10.1007/s10928-015-9424-2
Biomarker- versus drug-driven tumor growth inhibition models: an equivalence analysisMaria Luisa SarduEmail authorItalo PoggesiGiuseppe De Nicolaoyes?nohttps://link.springer.com/article/10.1007%2Fs10928-015-9427-z
A pharmacometric case study regarding the sensitivity of structural model parameter estimation to error in patient reported dosing timesJonathan KnightsEmail authorShashank RohatagiyesNMnohttps://link.springer.com/article/10.1007%2Fs10928-015-9428-y
Application of a Bayesian approach to physiological modelling of mavoglurant population pharmacokineticsThierry WendlingSwati DumitrasKayode OgungbenroLeon AaronsEmail authoryes?nohttps://link.springer.com/article/10.1007/s10928-015-9430-4
Modelling of drug-induced QT-interval prolongation: estimation approaches and translational opportunitiesEleonora MarosticaEmail authorKarel Van AmmelArd TeismanKoen BousseryJan Van BocxlaerFilip De RidderDavid GallacherAn VermeulenyesNMnohttps://link.springer.com/article/10.1007/s10928-015-9434-0
Modeling population heterogeneity in viral dynamics for chronic hepatitis C infection: Insights from Phase 3 telaprevir clinical studiesic L. HaseltineEmail authorHolly KimkoHaobin LuoJohn TolsmaDoug J. BartelsTara L. KiefferVarun Gargyes?nohttps://link.springer.com/article/10.1007/s10928-015-9435-z
Prediction and validation of enzyme and transporter off-targets for metforminSook Wah YeeLawrence LinMatthew MerskiMichael J. KeiserAakash GuptaYoucai ZhangHuan-Chieh ChienBrian K. ShoichetKathleen M. GiacominiEmail authorno?nohttps://link.springer.com/article/10.1007/s10928-015-9436-y
Mechanism-based mathematical modeling of combined gemcitabine and birinapant in pancreatic cancer cellsXu ZhuRobert M. StraubingerWilliam J. JuskoEmail authoryesAdaptnohttps://link.springer.com/article/10.1007/s10928-015-9429-x
Semi-mechanistic kidney model incorporating physiologically-relevant fluid reabsorption and transporter-mediated renal reabsorption: pharmacokinetics of γ-hydroxybutyric acid and l-lactate in ratsRutwij A. DaveMarilyn E. MorrisyesAdaptnohttps://link.springer.com/article/10.1007/s10928-015-9441-1
Bayesian population modeling of drug dosing adherenceKelly FellowsColin J. StonekingMurali Ramanathan???https://link.springer.com/article/10.1007/s10928-015-9439-8
Linking interleukin-6 receptor blockade with tocilizumab and its hematological effects using a modeling approachLeonid GibianskyEmail authorNicolas FreyyesNMnohttps://link.springer.com/article/10.1007/s10928-011-9227-z
Multi-response model for rheumatoid arthritis based on delay differential equations in collagen-induced arthritic mice treated with an anti-GM-CSF antibodyGilbert Koch Thomas Wagner Christine Plater-Zyberk Gezim Lahu Johannes SchroppyesADAPTyeshttps://link.springer.com/article/10.1007/s10928-011-9230-4